Brazil is an Indigenous land; over 60.3% of the Amazon Forest is in Brazil, and 385 Indigenous groups live there. They have ancestral knowledge on how to adapt, mitigate, and reduce climate disaster risks. However, Brazilian climate change legislation far from recognises the importance of Indigenous ontologies and knowledge in climate change response. Our research aim is to co-design climate change mitigation and adaptation actions and policies underpinned by Amazon Indigenous communities’ ontologies and knowledge values in responding to environmental challenges in Brazil. Climate change transformative Indigenous research requires the adoption of decolonizing methodologies. Therefore, our project is centred on Indigenous ontological pluralism in the context of global environmental change in the Amazon Biome. The research methodology is co-designed by four Amazon Indigenous ethnicities (Yawanawa, Noke Koi Katukina, Shanenawa, Huni Kuin) located in six communities in the Brazilian Amazon. The project comprises four Work Packages developed in 18 months.